Gonadorelin (gonadorelin) chemical name is 5 -- prolyl oxide a group of amyl-L monochromatic amyl-L a little amyl-L a tyrosyl-glycyl-l-l-arginyl-l-prolyl-glycamine, white or white like powder; Odorless. Have the ability to attract moisture. Dissolved in water, slightly dissolved in methanol, dissolved in 1% acetic acid solution. The molecular formula is C55H75N17O13, with a molecular weight of 1182.29000 and a density of 1.54. , is mainly used in clinical differential diagnosis of male or female due to hypothalamus or hypopituitarism caused by fertility disorders, gonadal atrophic gonadal insufficiency, galactorrhea amenorrhea, primary and secondary amenorrhea, menopause and premature menopause, pituitary tumors, pituitary organ damage and in fact hypothalamic dysfunction.
COA:
Function：
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is secreted by the hypothalamus in the body, which can stimulate the anterior pituitary gland to secrete gonadotropin, namely follicle stimulating hormone (FSH) and luteinizing hormone (LH); LH can promote the synthesis and secretion of androgens in male testicular interstitium, while LH and FSH can promote the synthesis and secretion of estrogen in female ovary.
When used continuously in clinical practice, GnRH has a biphasic effect on the pituitary gland. At the beginning, GnRH can promote the secretion of LH and FSH in the anterior pituitary gland and increase the plasma levels of LH, FSH and sex hormones. In the long run, GnRH can lead to the decrease of LHRH receptors in the pituitary gland and prevent the secretion of LH in the pituitary gland, thereby blocking the synthesis and secretion of testosterone and achieving the effect comparable to that of orchiectomy.
In women, the synthesis and secretion of estrogen can be blocked to achieve the effect of ovariectomy, so it can be used to treat hormone-dependent prostate cancer and breast cancer, and also applicable to endometriosis. It is mainly used as an ovulation stimulating drug to treat infertility and primary ovarian insufficiency caused by hypothalamic amenorrhea, especially for patients with ineffective clomiphene. It is also used in children with cryptorchidism and excessive androgen, pituitary tumors and so on.
The peak blood concentration was reached in 3 minutes after intravenous injection, and about 6 minutes after T1/2, the product was rapidly metabolized by the kidney and excreted. It has a faster and stronger effect on the increase of LH in plasma, but a slower and weaker effect on the increase of FSH。
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