Sleep is an indispensable physiological process to maintain human health. Sleep quality has an important impact on people's life and health. Therefore, more and more attention has been paid to the study of sleep. DSIP is the first sleep substance whose chemical structure has been elucidated. Some biological activities of DSIP have been found and applied in clinical practice. In the synthesis of DSIP, there are solution method, solid phase method, enzymatic method, etc.
A nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals.
In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
COA:
Function:
Roles in endocrine regulation;
Decreases basal corticotropin level and blocks its release;
Stimulates release of luteinizing hormones (LH);
Stimulates release of somatoliberi n and somatotrophi n secretion and inhibits somatostatin secretion;
Roles in physiological processes;
Can act as a stress limiting factor.
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