Sermorelinacetate is a synthetic growth hormone releasing hormone (GHRH) with 29 amino acid polypeptide. It is the amino terminal fragment of endogenous growth hormone releasing hormone (GHRH) and has significant growth regulation effect. Blacklock et al. proposed that neuropeptides/neurotransmitters, hormones and cytokines are the "common language" of mutual regulation among the three major systems: nervous system, endocrine system and immune system. In addition to its own very fine regulatory mechanism, the immune system is also regulated by the neuro-endocrine - immune network.
Features and Applications：Sermorelin acetate (SA) is a synthetic gh (growth hormone releasing hormone) composed of 29 amino acids. SA is the amino terminal fragment of endogenous GHRH and has significant growth regulation effect [1,2]. Its relative molecular weight (Mr) is 3 358.03.Sermorelin acetate (SA) is a synthetic gh (growth hormone releasing hormone) composed of 29 amino acids. SA is the amino terminal fragment of endogenous GHRH and has significant growth regulation effect [1,2]. Its relative molecular weight (Mr) is 3 358.03.Sermorelin is a synthetic peptide distinct from GHRH that stimulates the release of growth hormone from the pituitary gland. The results showed that sermorelin could antagonize the immunosuppression induced by cyclophosphamide in mice. In the body's immune system, macrophages play an important role in specific and nonspecific cellular immune function and immune regulation. The weight of thymus and spleen of the immune organs of mice with low immune function was increased significantly by shermeryn, and the phagocytic function of mononuclear phagocytic cells was improved, suggesting that shermeryn could enhance the non-specific immune function of mice. Cyclophosphamide could inhibit the proliferation of T lymphocytes, while chemorelin could significantly counter the toxic effect of CY on T lymphocytes and restore the proliferation of T lymphocytes.
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