Ketotifen fumarate, 4-(1-methyl-4-piperidylidene)-4Hbenzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogenfumarate (Zaditor), is a fine crystalline powder.Ketotifen is a ketothiophene isostere analog of the dibenzocycloheptaneantihistamines. The solution contains0.345 mg of ketotifen fumarate, which is equivalent to0.25 mg of ketotifen. The solution also contains the preservativebenzalkonium chloride (0.01%) as well as glycerol,sodium hydroxide and/or ** (to adjust pH),and purified water. It has a pH of 4.4 to 5.8 and an osmolalityof 210 to 300 mOsm/kg.
The recommended dose of ketotifen solution is 1 drop instilledinto each affected eye every 8 to 12 hours. The mostfrequently reported adverse reactions are conjunctival infection,headaches, and rhinitis. This drug product is for ocularadministration only and not for injection or oral use.Ketotifen solution should be used with caution during pregnancyor while nursing, because its safety has not been studiedunder these circumstances.
| Product name | Ketotifen fumarate |
| CAS NO. | 34580-14-8 |
| Appearance | White powder |
| MF | C23H23NO5S |
| MW | 425.5 |
| Melting Point | 192ºC |
| Purity | 99% |
| Valid Date | 24 Months |
| Storage Temp | Store at RT |
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Yxchuang today it has been graduallymove from singleness to high-tech mode enterprise, focusing on production,R&D, Sales andOEM. A large-scale enterprise with 55,000 square meter of modernized new factory buildings andoffice buildings, 35,000 square meter standardized clean room, 100,000 grade cleaned room, and2000 square meter high standard laboratory.
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