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A number of related compounds are known, the best known being unifiram.This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycinebinding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.
Cas 314728-85-3
Formula: C14H18N2O2
Molecular Weight 246.304
Melting point 94.5°C-95.5°C
Appearance Off-white to white crystalline powder
Asssy 99%+
1.Sunifiram activates AMPA-mediated neurotransmission.
2.Enhancing LTP in a bell-shaped dose-response relationship.
3.Sunifiram aids in the release of acetylcholine in the cerebral cortex.
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