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Tianeptine, an international drug product, is a serotonin reuptake facilitator antidepressant that is used for major depressive episodes (mild, moderate, or severe).
How long does Tianeptine sulfate stay in your system?
Its elimination half-life is 2.5 to 3 hours. The elimination half-life has been found to be increased to 4 to 9 hours in the elderly. The drug has an active metabolite, with a much longer elimination half-life. Tianeptine is excreted 65% in the urine and 15% in feces. depression research has formulated several key goals for the development of novel therapeutics, including faster onset of antidepressant effects, efficacy in treatment-resistant subjects and minimization of side effects.1 The atypical antidepressant tianeptine (Figure 1a), an agent with established clinical efficacy, already addresses several limitations of standard antidepressants.2 Namely, it shows fast effects against some depressive symptoms (cognitive and anxiety symptoms), is effective in patients resistant to selective serotonin reuptake inhibitor therapy3 and shows a better side effect profile compared with selective serotonin reuptake inhibitors and tricyclic antidepressants.2 Interestingly, unlike other tricyclic antidepressants, tianeptine does not inhibit biogenic amine transporters, and despite longstanding interest in this agent, its direct target, and thus its molecular mechanism of action, have remained elusiv.
Three forms of tianeptine on the market Tianeptine Sodium Salt ,Tianeptine Acid and Tianpetine Sulfate.
To know their differences,firstly you need to know why do so many medications appears as a salt form. A considerable proportion of drugs are organic acid or alkali salt, and often is a weak organic acid and strong inorganic base, weak organic base and strong inorganic acid salt. As a result of salt, so that some oil loaded organic acids or a few bases into a solid, is conducive to the preparation of some solid dosage forms; The salinization of drugs increases water solubility, which is beneficial to the preparation of some water-containing dosage forms, such as water injection and oral liquid. Into salt process, often also is a kind of purification process to remove the mixed cannot into salt impurities in the drug, but sometimes also can bring some problems worthy of note, for example, in the process of salt crystallization can adsorption and bag miscellaneous go into salt organic impurities (such as the reaction steps of raw materials or by-products), even if in the later recrystallization process is also difficult to completely remove them. At this point, it is necessary to pretreat the free organic acid or organic base of the drug before salt formation, and remove the impurities before salt formation
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