BPC 157 is also named: Bpc 15, Bpc-157, Booly protection compound 15. CAS NO.: 137525-51-0. BPC 157
(Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157
is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have
shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats.
The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an
injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium
while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts
outgrowths. Such outgrowths indicated tendon regeneration.The results revealed that the explants' outgrowth was significantly
accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, a MTT assay did show that
BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that
BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed
that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the
dispersal of the fibroblasts in culture dishes in a dose-dependent manner.
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Another animal study found that BPC 157's mechanism is angiomodulatory. Analysis showed it boosted angiogenesis in animals. Angiogenesis is the stimulating of new blood vessels, and therefore an indicator of both tissue healing and growth.
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