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Quinine, also known as cinchona, has a molecular formula of C20H24N2O2. It is the main alkaloid in the bark of Rubiaceae Cinchona and its genus. It is used to treat and prevent malaria and can treat scorched worms. Symptomatic drugs.
The discovery of quinine
Malaria used to be a rampant disease in tropical and subtropical regions, killing thousands of people. Indians in South America discovered that the bark of the cinchona tree can cure malaria. They peeled off the bark, dried it, and ground it into a powder to treat malaria. The Indians strictly guarded the secret of "Cinchona" and stipulated that anyone who leaked the secret of this medicine to foreigners would be subject to severe sanctions.
It is said that in the 17th century, a Spanish Count brought his beloved wife Ena to Lima, the capital of Peru. Unfortunately, his wife contracted malaria. An Indian girl looked after her. Seeing her condition was getting worse, she decided to treat her quietly. The earl quietly watched what she did. He thought that the Indian girl wanted to murder his wife and punish her. She had to tell the secret of the "cinchona tree". After Ena recovered, the Spaniard returned to Europe with this bark.
At the end of the 17th century, quinine was introduced into my country from Europe and was once called "cinchona cream". It was a very rare medicine at that time. Later, the Swedish scientist Linayus conducted a serious study on the bark of this plant, and extracted the effective ingredients, named it "quinine." The word "quinine" means bark in Peruvian script. As the medical demand for quinine increases, people hope that this natural medicine can be manufactured artificially. British chemist Hoffman imagined that quinine might be made from a derivative of kerosene, but did not succeed. It was not until 1945 that quinine was artificially synthesized.
Quinine has the effect of inhibiting the reproduction of the endoerythrocytic protozoan of falciparum malaria or killing it, and is an important antimalarial drug. Quinine also inhibits myocardial contractility and increases the rhythmic contraction of the uterus.
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