Adapalene is A new derivative of zeitaric acid, A synthetic third-generation retinoic acid. It has been approved by the Food and Drug Administration of the United States for the treatment of ulcerus vulgaris and keratosis, and the varieties are listed in the European Pharmacopoeia. Its solubility is poor, almost insoluble in water, the molecular formula is C28 H28 O3, the relative molecular weight is 412.52. Because of its strong receptor selectivity, small adverse reactions, low therapeutic concentration, and anti-inflammatory effect in the treatment of acne, it can effectively improve inflammatory skin lesions, so it has been widely used in clinical practice. The topical preparation of 0.1% adapaline gel has good anti-inflammatory and improved the differentiation ability of keratinocytes (keratinocytes). Clinically, it has good curative effect on acne, especially for the treatment of mild and moderate acne. Compared with other tretinoin, it has better tolerance and lower toxic side effects.
COA:
Function:
Adapalin belongs to the third generation of retinoic acid topical preparations, mainly used to treat mild to moderate acne, especially acne acne. The MAIN principle is to be able to adjust the keratinization of the skin, so that the keratinization plug of the hair follicle mouth keratinization is loose, fall off, and can promote the discharge of the sebum in the hair follicle
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