Sermorelinacetate is a synthetic growth hormone releasing hormone (GHRH) with 29 amino acid polypeptide. It is the amino terminal fragment of endogenous growth hormone releasing hormone (GHRH) and has significant growth regulation effect. Blacklock et al. proposed that neuropeptides/neurotransmitters, hormones and cytokines are the "common language" of mutual regulation among the three major systems: nervous system, endocrine system and immune system. In addition to its own very fine regulatory mechanism, the immune system is also regulated by the neuro-endocrine - immune network.、
| S'ermorelin Spefication | 2mg/vial |
| S'ermorelin Synonyms | S'ermorelin acetate hydrate |
| S'ermorelin CAS No. | 86168 78 7 |
| S'ermorelin M F | C149H246N44O42S |
| S'ermorelin M W | 3357.88 |
| S'ermorelin Usage | Oxidase inhibitor |
Function:
Products pharmacological：
Sermorelin is a synthetic peptide distinct from GHRH that stimulates the release of growth hormone from the pituitary gland. The results showed that sermorelin could antagonize the immunosuppression induced by cyclophosphamide in mice. Macrophages play an important role in specific and non-specific cellular immunity and immune regulation in the body's immune system. The weight of thymus and spleen of the immune organs of mice with low immune function was increased significantly by shermeryn, and the phagocytic function of mononuclear phagocytic cells was improved, suggesting that shermeryn could enhance the non-specific immune function of mice. Cyclophosphamide could inhibit the proliferation of T lymphocytes, while chemorelin could significantly counter the toxic effect of CY on T lymphocytes and restore the proliferation of T lymphocytes. Two nitrochlorobenzene (DNCB) is a kind of haptens, once the infiltration of the skin with skin protein combined into complete antigen, stimulate the T lymphocyte proliferation in sensitization lymphocytes, again contact DNCB produce delayed-type hypersensitivity, via the ear swelling degree can determine the cell immune function, Murray shed Chemicalbook forests increase immunosuppressive mice ear swelling Swelling degree. At the same time, it can also increase the content of IL-2, which is mainly produced by T lymphocytes, so it can also indirectly reflect the function of cellular immunity. These results suggest that semorielin can improve the cellular immune function of immunosuppressed mice, indicating that it has a certain immunomodulatory effect, which can restore the suppressed immune function to close to normal level, especially the effect of high dose. However, there is no significant difference between high dose and low dose, indicating no dose dependence. The mechanism may be through promoting the release of growth hormone (GH), a kind of anterior pituitary hormone, which has a wide impact on the immune system, almost all immune cells can promote differentiation and enhance the function of GH. The regulation of GH on the immune system may be through regulating the growth of lymphoid tissue
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